2'-O-Me Nucleosides
4',5'-Didehydro-2'-O-methyl-5-methyluridine
Quick view. 5-Methyluridine derivative bearing a 2'-O-methyl group and a terminal-methylene 4',5'-unsaturated sugar moiety. CAS 2095417-11-9. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
4',5'-Didehydro-2'-O-methyl-5-methyluridine is classified as 2'-o-me nucleosides (Formula C11H14N2O5; molecular weight 254.24 g/mol).
4',5'-Didehydro-2'-O-methyl-5-methyluridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 4',5'-Didehydro-2'-O-methyl-5-methyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- 2095417-11-9
Physicochemical data
| Nucleoside scaffold | 5-methyluridine |
|---|---|
| Sugar modification | 4',5'-didehydro terminal methylene |
| 2' modification | O-methyl |
| Calculated InChIKey | YVDWDRXYCAHSJC-NQMVMOMDSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 4',5'-Didehydro-2'-O-methyl-5-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2-Amino-2'-O-methyladenosine
2'-O-Me Nucleosides · CAS: 80791-87-3
BX-2OMN-00032'-O-Methyl-7-deazaadenosine
2'-O-Me Nucleosides · CAS: 68345-70-0
BX-2OMN-0004N6,2'-O-Dimethyladenosine
2'-O-Me Nucleosides · CAS: 57817-83-1
BX-2OMN-00052'-O-Methylinosine
2'-O-Me Nucleosides · CAS: 3881-21-8
BX-MN-01752'-O-Methylcytidine
2'-O-Me Nucleosides · CAS: 2140-72-9
BX-MN-01782'-O-Methylguanosine
2'-O-Me Nucleosides · CAS: 2140-71-8
Frequently asked questions
Can the package size for 4',5'-Didehydro-2'-O-methyl-5-methyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0041 and CAS 2095417-11-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.