Amino-modified Nucleosides
5'-Azido-5'-deoxy-2'-O-methyluridine
Quick view. We supply 5'-Azido-5'-deoxy-2'-O-methyluridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 194034-68-9. Catalog target purity: Specification on request.
Product profile
5'-Azido-5'-deoxy-2'-O-methyluridine is classified as nucleoside or protected nucleoside intermediate (Formula C10H13N5O5; molecular weight 283.24).
5'-Azido-5'-deoxy-2'-O-methyluridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-Azido-5'-deoxy-2'-O-methyluridine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- Uridine, 5'-azido-5'-deoxy-2'-O-methyl-
Useful catalog search terms
- CAS 194034-68-9
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification; azide click handle; amine functionality |
|---|---|
| InChI | InChI=1S/C10H13N5O5/c1-19-8-7(17)5(4-12-14-11)20-9(8)15-3-2-6(16)13-10(15)18/h2-3,5,7-9,17H,4H2,1H3,(H,13,16,18)/t5-,7-,8-,9-/m1/s |
| InChIKey | QQTLIVFPXXFWEK-ZOQUXTDFSA-N |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CN=[N+]=[N-])O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-Azido-5'-deoxy-2'-O-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-Azido-5'-deoxy-2'-O-methyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0154 and CAS 194034-68-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5'-Azido-5'-deoxy-2'-O-methyluridine or the named structural feature represented by this product.