Halogenated Nucleosides
5-fluoro-4'-thiouridine
Quick view. We supply 5-fluoro-4'-thiouridine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 56527-42-5. Catalog target purity: Specification on request.
Product profile
5-fluoro-4'-thiouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11FN2O5S; molecular weight 278.257).
5-fluoro-4'-thiouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5-fluoro-4'-thiouridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- NSC204983
- Uridine, 5-fluoro-4'-thio- (9CI)
Useful catalog search terms
- CAS 56527-42-5
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H11FN2O5S/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h,4-6,8,13-15H,2H2,(H,11,16,17) |
|---|---|
| InChIKey | FLAHATSCJQFZKB-UHFFFAOYSA-N |
| SMILES | O=c1nc(O)c(F)cn1C1SC(CO)C(O)C1O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-fluoro-4'-thiouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-fluoro-4'-thiouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0244 and CAS 56527-42-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.