Cyclic Dinucleotides
c-di-GMP
Quick view. We supply c-di-GMP for bacterial second-messenger, biofilm-signaling and cyclic-dinucleotide sensor research. CAS 61093-23-0. Catalog target purity: ≥98%.
Product profile
c-di-GMP is classified as cyclic dinucleotide second messenger or analog (Formula C20H24N10O14P2; molecular weight 690.41).
c-di-GMP can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
For c-di-GMP, reported solubility: Aqueous solubility is salt-form and concentration dependent; confirm the current lot specification before preparing a stock. Storage: Store sealed and dry; use the lot-specific CoA for the recommended temperature and hold time.
Names and search terms
Confirmed or normalized name variants
- Cyclic di-GMP
- Cyclic diguanosine monophosphate
- c-di-guanosine monophosphate
- 5GP-5GP
- cyclic diguanylate
- Cyclic-di-GMP(c-di-GMP)
- Cyclic-di-GMP,cyclic diguanylate
- bis(3',5')-cyclic diguanylic acid
Useful catalog search terms
- CAS 61093-23-0
- Cyclic Dinucleotides
- Cyclic dinucleotide second messenger or analog
- cyclic dinucleotide topology
Physicochemical data
| Key chemistry motifs | cyclic dinucleotide topology |
|---|---|
| Purity basis | Research-grade target; the lot-specific CoA reports the release result and analytical method. |
| Supply form | Dry research material |
| InChI | InChI=1S/C20H24N10O14P2/c21-19-25-13-7(15(33)27-19)23-3-29(13)17-9(31)11-5(41-17)1-39-45(35,36)44-12-6(2-40-46(37,38)43-11)42-18(10(12)32)30-4-24-8-14(30)26-20(22)28-16(8)34/h3-6,9-12,17-18,31-32H,1-2H2,(H,35,36)(H,37,38)(H3,21,25,27,33)(H3,22,26,28,34)/t5-,6-,9-,10-,11-,12-,17-,18-/m1/s |
| InChIKey | PKFDLKSEZWEFGL-MHARETSRSA-N |
| SMILES | O[C@@H]1[C@H](OP(OC[C@H]2O[C@@H](N3C(N=C(N)NC4=O)=C4N=C3)[C@H](O)[C@@H]2O5)(O)=O)[C@@H](COP5(O)=O)O[C@H]1N6C(N=C(N)NC7=O)=C7N=C6.C |
| Melting point | 193-196 °C (decomp) |
| Density | 2.70±0.1 g/cm3(Predicted) |
| pKa | 0.66±0.70(Predicted) |
| Form | powder |
| Color | white to beige |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Defined linkage isomers and counterion forms allow controlled comparisons across cyclic-dinucleotide assay conditions.
Method limitations
- Activity can depend on linkage stereochemistry, receptor variant, cell entry, salt form and assay format; molar calculations should use the exact supplied form.
These points describe c-di-GMP or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2',3'-cGAMP
Cyclic Dinucleotides · CAS: 1441190-66-4
BX-CDN-00022',3'-cGAMP sodium salt
Cyclic Dinucleotides · CAS: 2734858-36-5
BX-CDN-00032'3'-c-di-AM(PS)2 (Rp,Rp) disodium salt
Cyclic Dinucleotides · CAS: 1638750-95-4
BX-CDN-00043',3'-cGAMP
Cyclic Dinucleotides · CAS: 849214-04-6
BX-CDN-00052'3'-c-di-AM(PS)2 (Rp,Rp) ammonium salt
Cyclic Dinucleotides · CAS: 1638750-96-5
BX-CDN-00062'3'-c-di-AM(PS)2 (Rp,Rp)
Cyclic Dinucleotides · CAS: 1638241-89-0
Frequently asked questions
Can the package size for c-di-GMP be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CDN-0014 and CAS 61093-23-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Cyclic Dinucleotides product family and its named chemistry.
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
- Cyclic G(2',5')pA(3',5')p is the metazoan second messenger produced by cGAS
- STING is a direct innate immune sensor of cyclic di-GMP
- Cyclic di-AMP secreted by Listeria monocytogenes activates a host type I interferon response
