2'-F Nucleosides
2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine
Quick view. We supply 2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine as a 2'-fluoro nucleoside for modified nucleotide, amidite and nucleoside analog synthesis. CAS 139878-36-7. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine is classified as nucleoside or protected nucleoside intermediate (Formula C21H39FN2O5Si; molecular weight 474.71).
2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- Uridine, 2'-deoxy-3',5'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-
Useful catalog search terms
- CAS 139878-36-7
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- 2'-fluoro modification
- 2'-F Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection; 2'-fluoro modification |
|---|---|
| Density | 1.09±0.1 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0040 and CAS 139878-36-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry.