Protected Nucleosides
2'-O-TBDMS-rG(iBu)
Quick view. We supply 2'-O-TBDMS-rG(iBu) as a 2'-silyl protected guanosine intermediate for standard RNA phosphoramidite synthesis. CAS 182007-86-9. Catalog target purity: ≥95%.
Product profile
2'-O-TBDMS-rG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C20H33N5O6Si; molecular weight 467.59).
2'-O-TBDMS-rG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-TBDMS-rG(iBu), confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 2'-TBDMS-N2-ibu-rG
- 2'-O-TBDMS-N-ibu-rG
- 2'-O-TBDMS-N2-iBu-Gr
- 2'-O-TBDMS-N2-ibu-rG
- N2-Isobutyryl-2'-O-TBDMS-guanosine
- 2'-O-TBDMS-N2-isobutyryl-guanosine
- 2’-O-t-Butyldimethylsilyl-N2-isobutyryl guanosine
- 2'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine
Useful catalog search terms
- CAS 182007-86-9
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection |
|---|---|
| Density | 1.37±0.1 g/cm3(Predicted) |
| pKa | 9.16±0.20(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 2'-O-TBDMS-rG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0012 and CAS 182007-86-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.