Protected Nucleosides
5'-O-DMTr-2'-O-TBDMS-rC(Ac)
Quick view. We supply 5'-O-DMTr-2'-O-TBDMS-rC(Ac) as an acetyl-protected cytidine intermediate for RNA amidite production. CAS 121058-85-3. Catalog target purity: ≥95%.
Product profile
5'-O-DMTr-2'-O-TBDMS-rC(Ac) is classified as nucleoside or protected nucleoside intermediate (Formula C38H47N3O8Si; molecular weight 701.88).
5'-O-DMTr-2'-O-TBDMS-rC(Ac) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-O-TBDMS-rC(Ac), reported solubility: DMSO: 100 mg/mL (142.47 mM; Need ultrasonic). Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- 5'-DMT-2'-TBDMS-Ac-rC
- 5'-O-DMT-2'-O-TBDMS-Ac-rC
- 5-O-DMT-2-O-TBDMS-N-Ac-cytidin
- 5-O-DMT-2-O-TBDMS-N-Ac-cytidine
- 2'-O-TBDMS-5'-O-DMT-N4-Ac cytidin
- 5'-O-DMTr-2'-O-TBDMS-N4-acetylcytidine
- 5'-O-DMT-2'-O-TBDMS-N4-Acetyl-cytidine
- N4-Acetyl-2'-O-TBDMS-5'-O-DMT-cytidine
Useful catalog search terms
- CAS 121058-85-3
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- TBDMS protection
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; TBDMS protection |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| pKa | 10.18±0.20(Predicted) |
| Form | Solid |
| Color | White to off-white |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](O[Si](C(C)(C)C)(C)C)[C@@H]1O |&1:25,27,39,48,r| |
| InChIKey | ZFRWPAYPCFTQHK-XOBDVEPQNA-N |
| InChI | InChI=1S/C38H47N3O8Si/c1-25(42)39-32-22-23-41(36(44)40-32)35-34(49-50(7,8)37(2,3)4)33(43)31(48-35)24-47-38(26-12-10-9-11-13-26,27-14-18-29(45-5)19-15-27)28-16-20-30(46-6)21-17-28/h9-23,31,33-35,43H,24H2,1-8H3,(H,39,40,42,44)/t31-,33-,34-,35-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMT-2'-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-TBDMS-rC(Ac) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0043 and CAS 121058-85-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.