Amino-modified Nucleosides
3'-O-(2-Methoxyethyl)-2-aminoadenosine
Quick view. We supply 3'-O-(2-Methoxyethyl)-2-aminoadenosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 256224-02-9. Catalog target purity: Specification on request.
Product profile
3'-O-(2-Methoxyethyl)-2-aminoadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C13H20N6O5; molecular weight 340.34).
3'-O-(2-Methoxyethyl)-2-aminoadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-O-(2-Methoxyethyl)-2-aminoadenosine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 2-Amino-3'-O-(2-methoxyethyl)adenosine
- 3'-MOE-2-amino-Adenosine
- Adenosine, 2-amino-3'-O-(2-methoxyethyl)-
Useful catalog search terms
- CAS 256224-02-9
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification; amine functionality |
|---|---|
| InChI | InChI=1S/C13H20N6O5/c1-22-2-3-23-9-6(4-20)24-12(8(9)21)19-5-16-7-10(14)17-13(15)18-11(7)19/h5-6,8-9,12,20-21H,2-4H2,1H3,(H4,14,15,17,18)/t6-,8-,9-,12-/m1/s |
| InChIKey | CUAPZJHEUMOFCW-WOUKDFQISA-N |
| SMILES | COCCO[C@@H]1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C(N=C(N=C32)N)N)CO |
| Boiling point | 734.5±70.0 °C(Predicted) |
| Density | 1.81±0.1 g/cm3(Predicted) |
| pKa | 12.95±0.70(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-(2-Methoxyethyl)-2-aminoadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-(2-Methoxyethyl)-2-aminoadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0193 and CAS 256224-02-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry.