Amino-modified Nucleosides
5'-Azido-2',5'-dideoxyadenosine
Quick view. We supply 5'-Azido-2',5'-dideoxyadenosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 42204-43-3. Catalog target purity: Specification on request.
Product profile
5'-Azido-2',5'-dideoxyadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C10H15N8O2+; molecular weight 279.279).
5'-Azido-2',5'-dideoxyadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-Azido-2',5'-dideoxyadenosine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 9-(5-Azido-2,5-dideoxypentofuranosyl)-9H-purin-6-amine
- [5-(6-aminopurin-9-yl)-3-hydroxy-oxolan-2-yl]methylimino-imino-azanium
Useful catalog search terms
- CAS 42204-43-3
- Nucleoside or protected nucleoside intermediate
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle; amine functionality |
|---|---|
| InChI | InChI=1S/C10H12N8O2/c11-9-8-10(14-3-13-9)18(4-15-8)7-1-5(19)6(20-7)2-16-17-12/h3-7,19H,1-2H2,(H2,11,13,14) |
| InChIKey | GCTRYQSKALFXJD-UHFFFAOYSA-N |
| SMILES | [N-]=[N+]=NCC1OC(n2cnc3c(N)ncnc32)CC1O |
| Melting point | 78-79 °C (decomp) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 5'-Azido-2',5'-dideoxyadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-Azido-2',5'-dideoxyadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0211 and CAS 42204-43-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5'-Azido-2',5'-dideoxyadenosine or the named structural feature represented by this product.