Amino-modified Nucleosides
5'-Azido-5'-deoxyadenosine
Quick view. We supply 5'-Azido-5'-deoxyadenosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 737-76-8. Catalog target purity: Specification on request.
Product profile
5'-Azido-5'-deoxyadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C10H12N8O3; molecular weight 292.254).
5'-Azido-5'-deoxyadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-Azido-5'-deoxyadenosine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 9-(5-Azido-5-deoxypentofuranosyl)-9H-purin-6-amine
- NSC 98778
- 5'-Azidoadenosine
- 5'-Deoxy-5'-azidoadenosine
Useful catalog search terms
- CAS 737-76-8
- Nucleoside or protected nucleoside intermediate
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle; amine functionality |
|---|---|
| InChI | InChI=1S/C10H12N8O3/c11-8-5-9(14-2-13-8)18(3-15-5)10-7(20)6(19)4(21-10)1-16-17-12/h2-4,6-7,10,19-20H,1H2,(H2,11,13,14) |
| InChIKey | SKWSYTVBPHWKHX-UHFFFAOYSA-N |
| SMILES | [N-]=[N+]=NCC1OC(n2cnc3c(N)ncnc32)C(O)C1O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 5'-Azido-5'-deoxyadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
3'-NH₂-ddA
Amino-modified Nucleosides · CAS: 7403-25-0
BX-MN-00073'-NH₂-ddC
Amino-modified Nucleosides · CAS: 84472-90-2
BX-MN-00083'-NH₂-ddG
Amino-modified Nucleosides · CAS: 66323-49-7
BX-MN-00093'-NH₂-ddT
Amino-modified Nucleosides · CAS: 52450-18-7
BX-MN-01762-NH₂-rA
Amino-modified Nucleosides · CAS: 2096-10-8
BX-AMN-00026-Amino-4-methoxy-1-(2-deoxy-3,5-di-O-(p-toluoyl)--D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
Amino-modified Nucleosides · CAS: 100644-68-6
Frequently asked questions
Can the package size for 5'-Azido-5'-deoxyadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0231 and CAS 737-76-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5'-Azido-5'-deoxyadenosine or the named structural feature represented by this product.