Amino-modified Nucleosides
2'-Azido-2'-deoxycytidine
Quick view. We supply 2'-Azido-2'-deoxycytidine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 51034-68-5. Catalog target purity: Specification on request.
Product profile
2'-Azido-2'-deoxycytidine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12N6O4; molecular weight 268.23).
2'-Azido-2'-deoxycytidine — 2''-Azido-2''-deoxycytidine (cas# 51034-68-5) is a cytidine nucleoside analogue which is a versatile tool for chemical biology in synthesis, x-ray structure, and siRNA applications.
For 2'-Azido-2'-deoxycytidine, form: Solid.
Names and search terms
Confirmed or normalized name variants
- 1-(2-Azido-2-deoxypentofuranosyl)-4-imino-1,4-dihydropyrimidin-2-ol
- 2'-Azido-dC
- 2'-N3-2'-dC
- 2'-azidocytidine
- 2''-AZIDO-D-CYTIDINE
- Cytidine, 2'-azido-2'-deoxy-
- Cytidine,2'-azido-2'-deoxy- (9CI)
Useful catalog search terms
- CAS 51034-68-5
- Nucleoside or protected nucleoside intermediate
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle; amine functionality |
|---|---|
| InChI | InChI=1S/C9H12N6O4/c10-5-1-2-15(9(18)12-5)8-6(13-14-11)7(17)4(3-16)19-8/h1-2,4,6-8,16-17H,3H2,(H2,10,12,18) |
| InChIKey | FEOYKPQEERVCAV-UHFFFAOYSA-N |
| SMILES | [N-]=[N+]=NC1C(O)C(CO)OC1n1ccc(=N)nc1O |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-Azido-2'-deoxycytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 2'-Azido-2'-deoxycytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-Azido-2'-deoxycytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0220 and CAS 51034-68-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-Azido-2'-deoxycytidine or the named structural feature represented by this product.