Base-protected Nucleosides
2'-F-dG(iBu)
Quick view. We supply 2'-F-dG(iBu) as a protected 2'-fluoro nucleoside precursor for modified oligonucleotide and nucleotide synthesis. CAS 80681-25-0. Catalog target purity: Specification on request.
Product profile
2'-F-dG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C14H18FN5O5; molecular weight 355.32).
2'-F-dG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-F-dG(iBu), form: Solid.
Names and search terms
Confirmed or normalized name variants
- iBu-2'-F-dG
- N2-ibu-2'-F-dG
- 2'-Deoxy-2'-fluoro-N-isobutyrylguanosine
- N2-Isobutyryl-2'-Fluoro-2'-deoxyguanosine
- 2'-Deoxy-N2-isobutyryl-2'-fluoroguanosine
- N2-isobutyryl-2'-deoxy-2'-fluoroguanosine
- 2'-deoxy-N2-isobutyryl-2'-fluoro-2'-deoxyguanosine
- 2'-Deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine
Useful catalog search terms
- CAS 80681-25-0
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| Density | 1.78±0.1 g/cm3(Predicted) |
| pKa | 9.16±0.20(Predicted) |
| Form | Solid |
| SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](F)[C@@H]1O |
| InChIKey | SLHADUUWJSVYGQ-HTFXMJNNSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-F-iBu-G (2′-Deoxy-2′-fluoro-N-isobutyrylguanosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-dG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-F-dG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0110 and CAS 80681-25-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.