Amino-modified Nucleosides
2-Fluoro-3'-amino-2',3'-dideoxyadenosine
Quick view. A beta-D nucleoside bearing a 2-fluoroadenine base and a 3'-amino-2',3'-dideoxy sugar, CAS 1028809-83-7. CAS 1028809-83-7. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2-Fluoro-3'-amino-2',3'-dideoxyadenosine is classified as amino-modified nucleosides (Formula C10H13FN6O2; molecular weight 268.25).
2-Fluoro-3'-amino-2',3'-dideoxyadenosine provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 2-Fluoro-3'-amino-2',3'-dideoxyadenosine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 3'-Amino-2',3'-dideoxy-2-fluoroadenosine
- 9-(3-amino-2,3-dideoxy-beta-D-ribofuranosyl)-2-fluoroadenine
- 2-F-3'-NH2-ddA
- ABCR AB525160
- Metkinen 203-30
Useful catalog search terms
- CAS 1028809-83-7
- C10H13FN6O2
- SZVPVHHHZBIOFV-KVQBGUIXSA-N
Physicochemical data
| Nucleobase | 2-Fluoroadenine |
|---|---|
| Sugar modification | 3'-Amino and 2',3'-dideoxy |
| Free hydroxyl | 5'-OH |
| Stereochemistry | beta-D configuration with three defined sugar stereocenters |
| InChIKey | SZVPVHHHZBIOFV-KVQBGUIXSA-N |
| SMILES | Nc1nc(F)nc2c1ncn2[C@H]1C[C@H](N)[C@@H](CO)O1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2-Fluoro-3'-amino-2',3'-dideoxyadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2-Fluoro-3'-amino-2',3'-dideoxyadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0160 and CAS 1028809-83-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.