Modified Nucleotides
2'-O-4'-C-Locked-GTP Sodium Salt
Quick view. We supply 2'-O-4'-C-Locked-GTP Sodium Salt as a locked ribose GTP analog for modified nucleotide incorporation and duplex-stability research. CAS 1233876-29-3. Catalog target purity: Specification on request.
Product profile
2'-O-4'-C-Locked-GTP Sodium Salt is classified as nucleotide or nucleotide analog (Formula C11H16N5O14P3; molecular weight 535.19).
2'-O-4'-C-Locked-GTP Sodium Salt can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
For 2'-O-4'-C-Locked-GTP Sodium Salt, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- LNA-GTP Sodium Salt
- BX-MN-0113
Useful catalog search terms
- CAS 1233876-29-3
- Nucleotide or nucleotide analog
- conformationally locked sugar
- triphosphate group
- Modified Nucleotides
Physicochemical data
| Key chemistry motifs | conformationally locked sugar; triphosphate group |
|---|---|
| CAS context | The listed CAS refers to the parent/free-acid identity; confirm the supplied salt or counterion in the current specification. |
| Boiling point | 1013.6±75.0 °C(Predicted) |
| Density | 2.79±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) |
| pKa | 1.00±0.50(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 2'-O-4'-C-Locked-GTP Sodium Salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-4'-C-Locked-GTP Sodium Salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MODN-0169 and CAS 1233876-29-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-O-4'-C-Locked-GTP Sodium Salt or the named structural feature represented by this product.