2'-O-Me Nucleosides
2'-O-Methyl-N1-methyladenosine
Quick view. We supply 2'-O-Methyl-N1-methyladenosine as a 2'-O-methyl nucleoside for modified RNA monomer, nucleotide and analytical standard workflows. CAS 91101-00-7. Catalog target purity: Specification on request.
Product profile
2'-O-Methyl-N1-methyladenosine is classified as nucleoside or protected nucleoside intermediate (Formula C12H17N5O4; molecular weight 295.29).
2'-O-Methyl-N1-methyladenosine — N1,O2''-Dimethyladenosine is a naturally occurring modified ribonucleotide found in tRNA.
For 2'-O-Methyl-N1-methyladenosine, reported solubility: Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly). Storage: Hygroscopic, Refrigerator, under inert atmosphere.
Names and search terms
Confirmed or normalized name variants
- 2'-O-Methyl-1-methyladenosine
- N1,O2'-Dimethyladenosine
- 1,2'-O-dimethyladenosine
- Adenosine, 1-methyl-2'-O-methyl-
- (2R,3R,4R,5R)-5-(6-amino-1-methyl-2H-purin-9-yl)-2-(hydroxymethyl)-4-m ethoxy-oxolan-3-ol
Useful catalog search terms
- CAS 91101-00-7
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- 2'-O-Me Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| InChI | InChI=1S/C12H19N5O4/c1-16-4-15-11-7(10(16)13)14-5-17(11)12-9(20-2)8(19)6(3-18)21-12/h5-6,8-9,12,18-19H,3-4,13H2,1-2H3/t6-,8-,9-,12-/m1/s |
| InChIKey | BFQBUUCXUMVPLW-WOUKDFQISA-N |
| SMILES | CN1CN=C2C(=C1N)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OC |
| Melting point | >115°C (dec.) |
| Boiling point | 612.0±65.0 °C(Predicted) |
| Density | 1.69±0.1 g/cm3(Predicted) |
| pKa | 13.22±0.70(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-Methyl-N1-methyladenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-N1-methyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Methyl-N1-methyladenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0113 and CAS 91101-00-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry.