2'-O-MOE Nucleosides
2'-O-MOE-5-Me-rU
Quick view. We supply 2'-O-MOE-5-Me-rU as a methoxyethyl 5-methyl uridine/thymidine analog for ASO chemistry. CAS 163759-49-7. Catalog target purity: Specification on request.
Product profile
2'-O-MOE-5-Me-rU is classified as nucleoside or protected nucleoside intermediate (Formula C13H20N2O7; molecular weight 316.31).
2'-O-MOE-5-Me-rU — 2'-O-(2-Methoxyethyl)-5-methyluridine is a protected uridine derivative and nucleoside used in the preparation of synthetic nucleic acids.
For 2'-O-MOE-5-Me-rU, reported solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated). Storage: Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-Tr
- 5-Me-2'-O-MOE U
- 5-Me-2'-O-MOE Uridine
- 2'-O-MOE-5-Methyluridin
- 2'-O-Methoxyethyl-thyminde
- 2'-O-(2-Methoxyethy)-5-methyluridine
- 2'-O-(2-Methoxyethyl)-5-methyluridine
- Uridine, 2'-O-(2-Methoxyethyl)-5-Methyl-
Useful catalog search terms
- CAS 163759-49-7
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- 2'-O-MOE Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification |
|---|---|
| Melting point | 115.5-116.5 °C |
| Density | 1.41 |
| pKa | 9.55±0.10(Predicted) |
| Form | Solid |
| Color | Off-White |
| SMILES | OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OCCOC)[C@@H]1O |
| InChI | InChI=1S/C13H20N2O7/c1-7-5-15(13(19)14-11(7)18)12-10(21-4-3-20-2)9(17)8(6-16)22-12/h5,8-10,12,16-17H,3-4,6H2,1-2H3,(H,14,18,19)/t8-,9-,10-,12-/m1/s |
| InChIKey | NEVQCHBUJFYGQO-DNRKLUKYSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-MOE-5-Me-rU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-5-Me-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-MOE-5-Me-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0174 and CAS 163759-49-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry.