2'-O-MOE Nucleosides
2'-O-MOE-rI
Quick view. We supply 2'-O-MOE-rI as a 2'-O-MOE nucleoside for antisense oligonucleotide monomer and analog synthesis. CAS 545374-76-3. Catalog target purity: ≥98%.
Product profile
2'-O-MOE-rI is classified as nucleoside or protected nucleoside intermediate (Formula C13H18N4O6; molecular weight 326.31).
2'-O-MOE-rI can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-MOE-rI, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 2'-o-methoxyethyl inosine
- 2'-O-(2-Methoxyethyl) inosine
- Inosine, 2'-O-(2-methoxyethyl)-
Useful catalog search terms
- CAS 545374-76-3
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- 2'-O-MOE Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification |
|---|---|
| SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)O)N=C2)[C@H](OCCOC)[C@@H]1O |
| InChI | InChI=1S/C13H18N4O6/c1-21-2-3-22-10-9(19)7(4-18)23-13(10)17-6-16-8-11(17)14-5-15-12(8)20/h5-7,9-10,13,18-19H,2-4H2,1H3,(H,14,15,20)/t7-,9-,10-,13-/m1/s |
| InChIKey | YVCRYUJBJVEBAK-QYVSTXNMSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-rI or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2'-O-MOE-5-Me-rC
2'-O-MOE Nucleosides · CAS: 244105-55-3
BX-MN-01682'-O-MOE-rG
2'-O-MOE Nucleosides · CAS: 473278-54-5
BX-MN-01692'-O-MOE-rA
2'-O-MOE Nucleosides · CAS: 168427-74-5
BX-MN-01702'-O-MOE-rC
2'-O-MOE Nucleosides · CAS: 223777-16-0
BX-MN-01712'-O-MOE-rU
2'-O-MOE Nucleosides · CAS: 223777-15-9
BX-MN-01742'-O-MOE-5-Me-rU
2'-O-MOE Nucleosides · CAS: 163759-49-7
Frequently asked questions
Can the package size for 2'-O-MOE-rI be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0001 and CAS 545374-76-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry.