2'-O-MOE Nucleosides
2'-O-MOE-rU
Quick view. We supply 2'-O-MOE-rU as a methoxyethyl uridine nucleoside for modified RNA/ASO building blocks. CAS 223777-15-9. Catalog target purity: Specification on request.
Product profile
2'-O-MOE-rU is classified as nucleoside or protected nucleoside intermediate (Formula C12H18N2O7; molecular weight 302.28).
2'-O-MOE-rU — 2'-O-(2-Methoxyethyl)uridine is a Uridine derivative as building blocks for cross-linking oligonucleotides.
For 2'-O-MOE-rU, storage: 4°C, protect from light. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE Uridine
- 2'-O-(2-Methoxyethy)uridine
- 2'-O-(2-Methoxyethyl)uridine
- Uridine, 2'-O-(2-methoxyethyl)-
- 2'-O-(2-Methoxyethyl)uridine USP/EP/BP
Useful catalog search terms
- CAS 223777-15-9
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- 2'-O-MOE Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification |
|---|---|
| Density | 1.46±0.1 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
| Form | Solid |
| Color | White to off-white |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OCCOC)[C@@H]1O |
| InChI | InChI=1S/C12H18N2O7/c1-19-4-5-20-10-9(17)7(6-15)21-11(10)14-3-2-8(16)13-12(14)18/h2-3,7,9-11,15,17H,4-6H2,1H3,(H,13,16,18)/t7-,9-,10-,11-/m1/s |
| InChIKey | XTXNROBDOKPICP-QCNRFFRDSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-MOE-rU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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Frequently asked questions
Can the package size for 2'-O-MOE-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0171 and CAS 223777-15-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry.