Base-protected Nucleosides
2'-O-propargyl-rG(iBu)
Quick view. We supply 2'-O-propargyl-rG(iBu) as a protected 2'-O-propargyl nucleoside intermediate for click-compatible oligonucleotide building blocks. CAS 2095417-55-1. Catalog target purity: Specification on request.
Product profile
2'-O-propargyl-rG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C17H21N5O6; molecular weight 391.379).
2'-O-propargyl-rG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-propargyl-rG(iBu), copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- N2-iso-Butyroyl-2'-O-propargylguanosine
Useful catalog search terms
- CAS 2095417-55-1
- Nucleoside or protected nucleoside intermediate
- alkyne click handle
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | alkyne click handle |
|---|---|
| Density | 1.56±0.1 g/cm3(Predicted) |
| pKa | 8.68±0.20(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 2'-O-propargyl-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-propargyl-rG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0085 and CAS 2095417-55-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-O-propargyl-rG(iBu) or the named structural feature represented by this product.