Amino-modified Nucleosides
5'-Azido-2',5'-dideoxyuridine
Quick view. We supply 5'-Azido-2',5'-dideoxyuridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 35959-37-6. Catalog target purity: Specification on request.
Product profile
5'-Azido-2',5'-dideoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11N5O4; molecular weight 253.22).
5'-Azido-2',5'-dideoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-Azido-2',5'-dideoxyuridine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- Uridine, 5'-azido-2',5'-dideoxy-
Useful catalog search terms
- CAS 35959-37-6
- Nucleoside or protected nucleoside intermediate
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle; amine functionality |
|---|---|
| InChI | InChI=1S/C9H11N5O4/c10-13-11-4-6-5(15)3-8(18-6)14-2-1-7(16)12-9(14)17/h1-2,5-6,8,15H,3-4H2,(H,12,16,17)/t5-,6+,8+/m0/s |
| InChIKey | VAGBIQTXMSHWJX-SHYZEUOFSA-N |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CN=[N+]=[N-])O |
| Melting point | 139-140 °C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 5'-Azido-2',5'-dideoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-Azido-2',5'-dideoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0206 and CAS 35959-37-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5'-Azido-2',5'-dideoxyuridine or the named structural feature represented by this product.