2'-O-MOE Nucleosides
5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine
Quick view. We supply 5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine as a 2'-O-MOE nucleoside for antisense oligonucleotide monomer and analog synthesis. CAS 2095417-60-8. Catalog target purity: Specification on request.
Structure confirmation
This item requires structure confirmation before quotation. Send the target structure, CAS number, SMILES, InChI or drawing for our technical review.
Canonical name plus a structure drawing, SMILES, InChI or unambiguous CAS number.
Protecting groups, stereochemistry, salt or counterion, hydration and requested form.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine is classified as nucleoside or protected nucleoside intermediate.
5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Useful catalog search terms
- CAS 2095417-60-8
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- azide click handle
- 2'-O-MOE Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification; azide click handle |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2MOE-0011 and CAS 2095417-60-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine or the named structural feature represented by this product.