2'-O-Me Nucleosides
5'-Deoxy-5'-iodo-2'-O-methyl-5-methyluridine
Quick view. A 5-methyluridine nucleoside bearing 5'-deoxy-5'-iodo and 2'-O-methyl substitutions, CAS 187733-72-8. CAS 187733-72-8. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-Deoxy-5'-iodo-2'-O-methyl-5-methyluridine is classified as 2'-o-me nucleosides (Formula C11H15IN2O5; molecular weight 382.15).
5'-Deoxy-5'-iodo-2'-O-methyl-5-methyluridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5'-Deoxy-5'-iodo-2'-O-methyl-5-methyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-deoxy-5'-iodo-5-methyl-2'-O-methyluridine
- Uridine, 5'-deoxy-5'-iodo-5-methyl-2'-O-methyl-
Useful catalog search terms
- CAS 187733-72-8
- C11H15IN2O5
- HTLVQJXEEODLKI-FDDDBJFASA-N
Physicochemical data
| Sugar substitution | 2'-O-methyl |
|---|---|
| 5'-substitution | 5'-Deoxy-5'-iodo |
| Nucleobase substitution | 5-Methyluracil |
| Free hydroxyl | 3'-OH |
| Stereochemistry | Assigned ribofuranosyl configuration |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-Deoxy-5'-iodo-2'-O-methyl-5-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2-Amino-2'-O-methyladenosine
2'-O-Me Nucleosides · CAS: 80791-87-3
BX-2OMN-00032'-O-Methyl-7-deazaadenosine
2'-O-Me Nucleosides · CAS: 68345-70-0
BX-2OMN-0004N6,2'-O-Dimethyladenosine
2'-O-Me Nucleosides · CAS: 57817-83-1
BX-2OMN-00052'-O-Methylinosine
2'-O-Me Nucleosides · CAS: 3881-21-8
BX-MN-01752'-O-Methylcytidine
2'-O-Me Nucleosides · CAS: 2140-72-9
BX-MN-01782'-O-Methylguanosine
2'-O-Me Nucleosides · CAS: 2140-71-8
Frequently asked questions
Can the package size for 5'-Deoxy-5'-iodo-2'-O-methyl-5-methyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0028 and CAS 187733-72-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.