2'-O-Me Nucleosides
8-Chloro-2'-O-methyl adenosine
Quick view. We supply 8-Chloro-2'-O-methyl adenosine as a 2'-O-methyl nucleoside for modified RNA monomer, nucleotide and analytical standard workflows. CAS 634207-55-9. Catalog target purity: Specification on request.
Product profile
8-Chloro-2'-O-methyl adenosine is classified as nucleoside or protected nucleoside intermediate (Formula C11H14ClN5O4; molecular weight 315.71).
8-Chloro-2'-O-methyl adenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 8-Chloro-2'-O-methyl adenosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- Adenosine, 8-chloro-2'-O-methyl- (9CI)
Useful catalog search terms
- CAS 634207-55-9
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- 2'-O-Me Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| InChI | InChI=1S/C11H14ClN5O4/c1-20-7-6(19)4(2-18)21-10(7)17-9-5(16-11(17)12)8(13)14-3-15-9/h3-4,6-7,10,18-19H,2H2,1H3,(H2,13,14,15)/t4-,6-,7-,10-/m1/s |
| InChIKey | IXTQMSFHXDXWKT-KQYNXXCUSA-N |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C3=NC=NC(=C3N=C2Cl)N)CO)O |
| Boiling point | 656.3±65.0 °C(Predicted) |
| Density | 1.94±0.1 g/cm3(Predicted) |
| pKa | 12.99±0.70(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 8-Chloro-2'-O-methyl adenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2'-O-Me-2-NH₂-rA
2'-O-Me Nucleosides · CAS: 80791-87-3
BX-2OMN-00032'-O-Me-7-deaza-rA
2'-O-Me Nucleosides · CAS: 68345-70-0
BX-2OMN-00042'-O-Me-N6-Me-rA
2'-O-Me Nucleosides · CAS: 57817-83-1
BX-2OMN-00052'-O-Me-rI
2'-O-Me Nucleosides · CAS: 3881-21-8
BX-MN-01752'-O-Me-rC
2'-O-Me Nucleosides · CAS: 2140-72-9
BX-MN-01782'-O-Me-rG
2'-O-Me Nucleosides · CAS: 2140-71-8
Frequently asked questions
Can the package size for 8-Chloro-2'-O-methyl adenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0101 and CAS 634207-55-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry.