Modified Nucleotides
N1-Methylpseudouridine-5'-triphosphate
Quick view. We supply N1-methylpseudouridine-5'-triphosphate as a dry modified ribonucleotide for mRNA transcription and RNA-translation research. CAS 1428903-59-6. Catalog target purity: ≥99%.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
N1-Methylpseudouridine-5'-triphosphate is classified as nucleotide or nucleotide analog (Formula C10H17N2O15P3; molecular weight 498.17).
N1-Methylpseudouridine-5'-triphosphate can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
For N1-Methylpseudouridine-5'-triphosphate, storage: -20°C, sealed storage, away from moisture. Form: N1-Methyl-Pseudouridine-5'-Triphosphate is a solution in water.
Names and search terms
Confirmed or normalized name variants
- N1-Me-Pseudo-UTP
- 1-Methylpseudouridine-5'-triphosphate
- m1ΨTP
- abs60156
- N1-Methylpseudo-UTP
- N1-Methyl Pseudouridine-5'-Triphosphate, trisodium Salt
Useful catalog search terms
- CAS 1428903-59-6
- Nucleotide or nucleotide analog
- triphosphate group
- Modified Nucleotides
Physicochemical data
| Key chemistry motifs | triphosphate group |
|---|---|
| Base modification | N1-methylpseudouridine |
| Supply form | Dry research material |
| Density | 2.010±0.06 g/cm3(Predicted) |
| pKa | 0.97±0.50(Predicted) |
| Form | N1-Methyl-Pseudouridine-5'-Triphosphate is a solution in water. |
| Color | N1-Methyl-Pseudouridine-5'-Triphosphate is a colorless to slightly yellow. |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1C1=CN(C)C(=O)NC1=O)O |&1:1,2,3,19,r| |
| InChIKey | OLRONOIBERDKRE-CAYFCZNJNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 1-Methylpseudouridine-5'-triphosphate Sodium Salt is a salt analogue of 1-Methylpseudouridine-5'-triphosphate, which can be used to optimize the cardiac delivery of modified mRNA
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Base modifications can tune RNA stability, translation behavior, duplex properties or analytical discrimination versus native bases.
Method limitations
- Modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
These points describe N1-Methylpseudouridine-5'-triphosphate or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N1-Methylpseudouridine-5'-triphosphate be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-GSS-0046 and CAS 1428903-59-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss N1-Methylpseudouridine-5'-triphosphate or the named structural feature represented by this product.
- Pseudouridine-modified mRNA performance study
- Synthetic mRNA capping review
- Human adipose-derived multipotent stromal cells enriched with IL-10 modRNA improve diabetic wound healing: Trigger the macrophage phenotype shift. (2025)
- Development of a retention prediction model in ion-pair reversed-phase HPLC for nucleoside triphosphates used as mRNA vaccine raw materials. (2022)
- Optimizing Cardiac Delivery of Modified mRNA. (2017)