Amino-modified Nucleosides
Uridine-5-methylamino acetic acid
Quick view. We supply Uridine-5-methylamino acetic acid as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 69181-26-6. Catalog target purity: Specification on request.
Product profile
Uridine-5-methylamino acetic acid is classified as nucleoside or protected nucleoside intermediate (Formula C12H17N3O8; molecular weight 331.28 g/mol (calculated from molecular formula)).
Uridine-5-methylamino acetic acid — 5-Carboxymethylaminomethyluridine or cmnm5U, is a modification of tRNA responsible for restricting codon-anticodon wobbling and recognition of purine-ending codons. This modification can be catalyzed by the action of GidA and MnmE enzymes on uridine.
For Uridine-5-methylamino acetic acid, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 5-(carboxymethylaminomethyl)uridine
- Uridine-5-methylamino acetic acid RNA-modified nucleoside cmnm5U
Useful catalog search terms
- CAS 69181-26-6
- Nucleoside or protected nucleoside intermediate
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | amine functionality |
|---|---|
| InChI | InChI=1S/C12H17N3O8/c16-4-6-8(19)9(20)11(23-6)15-3-5(1-13-2-7(17)18)10(21)14-12(15)22/h,6,8-9,11,13,16,19-20H,1-2,4H2,(H,17,18)(H,14,21,22)/t6-,8-,9-,11-/m1/s |
| InChIKey | VSCNRXVDHRNJOA-PNHWDRBUSA-N |
| SMILES | C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)CNCC(=O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Uridine-5-methylamino acetic acid can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe Uridine-5-methylamino acetic acid or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for Uridine-5-methylamino acetic acid be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0228 and CAS 69181-26-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry.