Modified Nucleosides
N1-Methyl-3'-O-methylguanosine
Quick view. A stereodefined guanosine nucleoside methylated at N1 and the ribose 3'-oxygen, identified by CAS 74466-66-3. CAS 74466-66-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
N1-Methyl-3'-O-methylguanosine is classified as modified nucleosides (Formula C12H17N5O5; molecular weight 311.29).
N1-Methyl-3'-O-methylguanosine can be evaluated in terminally blocked nucleotide, cap-chemistry and analytical-reference workflows where 3′-O-methylation changes extension or end-group reactivity.
For N1-Methyl-3'-O-methylguanosine, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- 1,3'-Dimethylguanosine
- Guanosine, 1-methyl-3'-O-methyl-
Useful catalog search terms
- CAS 74466-66-3
- PubChem CID 131884455
Physicochemical data
| Nucleobase modification | N1-methyl |
|---|---|
| Sugar modification | 3'-O-methyl |
| InChIKey | FKWCSDZDAGWXEN-IOSLPCCCSA-N |
| PubChem CID | 131884455 |
| InChI | InChI=1S/C12H17N5O5/c1-16-10(20)6-9(15-12(16)13)17(4-14-6)11-7(19)8(21-2)5(3-18)22-11/h4-5,7-8,11,18-19H,3H2,1-2H3,(H2,13,15)/t5-,7-,8-,11-/m1/s1 |
| SMILES | CN1C(=O)C2=C(N=C1N)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)OC)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe N1-Methyl-3'-O-methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N1-Methyl-3'-O-methylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0665 and CAS 74466-66-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.