Halogenated Nucleosides
2',3'-Didehydro-2',3'-dideoxy-5-fluorouridine
Quick view. A 5-fluoro-modified uridine analog with a 2',3'-unsaturated dideoxy sugar for structure-specific nucleoside and nucleotide research. CAS 15379-29-0. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2',3'-Didehydro-2',3'-dideoxy-5-fluorouridine is classified as halogenated nucleosides (Formula C9H9FN2O4; molecular weight 228.18).
2',3'-Didehydro-2',3'-dideoxy-5-fluorouridine — Fluorinated didehydro nucleoside reference or building block for structure-specific nucleoside and nucleotide research.
For 2',3'-Didehydro-2',3'-dideoxy-5-fluorouridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- FddddU
- 2',3'-Dideoxy-2',3'-didehydro-5-fluoro-uridine
Useful catalog search terms
- CAS 15379-29-0
Physicochemical data
| SMILES | O=C1N([C@@H]2O[C@H](CO)C=C2)C=C(F)C(=O)N1 |
|---|---|
| Nucleobase modification | 5-fluoro |
| Sugar modification | 2',3'-didehydro-2',3'-dideoxy |
| InChI | InChI=1S/C9H9FN2O4/c10-6-3-12(9(15)11-8(6)14)7-2-1-5(4-13)16-7/h1-3,5,7,13H,4H2,(H,11,14,15) |
| InChIKey | SHVSSJHFEDAZCZ-UHFFFAOYSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3'-Didehydro-2',3'-dideoxy-5-fluorouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Trifluridine
Halogenated Nucleosides · CAS: 70-00-8
BX-HN-00026-Chloropurine 2'-deoxyriboside
Halogenated Nucleosides · CAS: 4594-45-0
BX-HN-00038-Chloro-2'-deoxyadenosine
Halogenated Nucleosides · CAS: 85562-55-6
BX-HN-00042'-Chloro-2'-deoxycytidine
Halogenated Nucleosides · CAS: 10212-19-8
BX-HN-00055-Bromo-2'-deoxycytidine
Halogenated Nucleosides · CAS: 1022-79-3
BX-HN-01535-Fluoro-2'-deoxycytidine
Halogenated Nucleosides · CAS: 10356-76-0
Frequently asked questions
Can the package size for 2',3'-Didehydro-2',3'-dideoxy-5-fluorouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0172 and CAS 15379-29-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.