Halogenated Nucleosides
2'-5-CF3-dU
Quick view. We supply 2'-5-CF3-dU as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 70-00-8. Catalog target purity: ≥98%.
Product profile
2'-5-CF3-dU is classified as nucleoside or protected nucleoside intermediate (Formula C10H11F3N2O5; molecular weight 296.2).
2'-5-CF3-dU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-5-CF3-dU, reported solubility: Soluble in DMSO (up to 25 mg/ml) or in Water (up to 14 mg/ml). Storage: −20°C.
Names and search terms
Confirmed or normalized name variants
- 2'-DEOXY-5-TRIFLUOROMETHYLURIDINE
- 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE
- ALPHA,ALPHA,ALPHA-TRIFLUOROTHYMIDINE
- F3TDR
- TFT
- TRIFLUORO-D-THYMIDINE
- TRIFLUOROTHYMIDINE
- TRIFLUOROTHYMINE DEOXYRIBOSIDE
Useful catalog search terms
- CAS 70-00-8
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| Melting point | 190-193 °C (lit.) |
|---|---|
| Density | 1.4365 (estimate) |
| pKa | pKa 7.85 (Uncertain) |
| Form | solid |
| Color | Off-white |
| SMILES | [C@H]1(O)[C@@H](CO)O[C@@H](N2C=C(C(F)(F)F)C(=O)NC2=O)C1 |
| InChI | InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6-,7-/m1/s |
| InChIKey | VSQQQLOSPVPRAZ-FSDSQADBSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 2'-5-CF3-dU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0001 and CAS 70-00-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.