Halogenated Nucleosides
2',3'-Dideoxy-3'-fluoroadenosine
Quick view. An adenosine derivative bearing 2'-deoxy and 3'-fluoro sugar modifications, identified by CAS 87418-35-7. CAS 87418-35-7. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2',3'-Dideoxy-3'-fluoroadenosine is classified as halogenated nucleosides (Formula C10H12FN5O2; molecular weight 253.23).
A retained 2003 Nucleosides, Nucleotides & Nucleic Acids paper reports preparation of phosphoramidate derivatives from 2',3'-dideoxy-3'-fluoroadenosine (PMID 14609234; DOI 10.1081/NCN-120025242).
For 2',3'-Dideoxy-3'-fluoroadenosine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 9-(3-Fluoro-2,3-dideoxy-beta-D-erythro-pentofuranosyl)adenine
- 3'-Fluoro-2',3'-dideoxyadenosine
Useful catalog search terms
- CAS 87418-35-7
- CTDUJDNZPPZTAV-RRKCRQDMSA-N
Physicochemical data
| InChIKey | CTDUJDNZPPZTAV-RRKCRQDMSA-N |
|---|---|
| Nucleoside scaffold | adenosine |
| Sugar modifications | 2'-deoxy and 3'-fluoro |
| Free hydroxyl | 5'-OH |
| InChI | InChI=1S/C10H12FN5O2/c11-5-1-7(18-6(5)2-17)16-4-15-8-9(12)13-3-14-10(8)16/h3-7,17H,1-2H2,(H2,12,13,14)/t5-,6+,7+/m0/s1 |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N)CO)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3'-Dideoxy-3'-fluoroadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',3'-Dideoxy-3'-fluoroadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0260 and CAS 87418-35-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not a BX Lab lot specification or product-performance claim.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.