Halogenated Nucleosides
2',3'-Dideoxy-5-fluorocytidine
Quick view. We supply 2',3'-Dideoxy-5-fluorocytidine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 107036-62-4. Catalog target purity: Specification on request.
Product profile
2',3'-Dideoxy-5-fluorocytidine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12FN3O3; molecular weight 229.21).
2',3'-Dideoxy-5-fluorocytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2',3'-Dideoxy-5-fluorocytidine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Cytidine, 2', -3', -dideoxy-5-fluoro-
- 5-F-Ddc
- β-D-FddC
- Aids000043
- .beta.-D-Fddc
- .beta.-D-5-F-Ddc
- 5-fluoro-2',3'-dideoxycytidine
- 2',3'-Dideoxy-5-fluorocytidine, 5FddC
Useful catalog search terms
- CAS 107036-62-4
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H12FN3O3/c10-6-3-13(9(15)12-8(6)11)7-2-1-5(4-14)16-7/h,5,7,14H,1-2,4H2,(H2,11,12,15)/t5-,7+/m0/s |
|---|---|
| InChIKey | QBEIABZPRBJOFU-CAHLUQPWSA-N |
| SMILES | C1C[C@@H](O[C@@H]1CO)N2C=C(C(=NC2=O)N)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3'-Dideoxy-5-fluorocytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',3'-Dideoxy-5-fluorocytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0154 and CAS 107036-62-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.