Halogenated Nucleosides
2',5'-Dideoxy-5'-iodouridine
Quick view. A uridine analogue with a 2',5'-dideoxy sugar and iodine at the terminal sugar 5' position, while retaining an unsubstituted uracil base. CAS 58510-66-0. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2',5'-Dideoxy-5'-iodouridine is classified as 5'-iodinated dideoxy uridine nucleoside (Formula C9H11IN2O4; molecular weight 338.10 g/mol).
2',5'-Dideoxy-5'-iodouridine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 2',5'-Dideoxy-5'-iodouridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 1-[(2R,4S,5S)-4-Hydroxy-5-(iodomethyl)oxolan-2-yl]pyrimidine-2,4-dione
Useful catalog search terms
- 58510-66-0
- PubChem CID 14562600
- CHEMBL2032104
Physicochemical data
| PubChem CID | 14562600 |
|---|---|
| ChEMBL ID | CHEMBL2032104 |
| DSSTox ID | DTXSID60561682 |
| InChIKey | JYWLLSHCWALPBJ-SHYZEUOFSA-N |
| InChI | InChI=1S/C9H11IN2O4/c10-4-6-5(13)3-8(16-6)12-2-1-7(14)11-9(12)15/h1-2,5-6,8,13H,3-4H2,(H,11,14,15)/t5-,6+,8+/m0/s1 |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CI)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 2',5'-Dideoxy-5'-iodouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',5'-Dideoxy-5'-iodouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0124 and CAS 58510-66-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.