Amino-modified Nucleosides
2'-Amino-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine
Quick view. A uridine derivative bearing a 2'-amino-2'-deoxy sugar modification and a 5'-O-(4,4'-dimethoxytrityl) protecting group, CAS 174221-86-4. CAS 174221-86-4. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-Amino-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine is classified as amino-modified nucleosides (Formula C30H31N3O7; molecular weight 545.58).
2'-Amino-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine — Reported as compound 4, an intermediate in the published preparation of a 2'-formamidouridine phosphoramidite (Nomura et al., 2024).
For 2'-Amino-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 2'-Amino-2'-deoxy-5'-O-DMTr-uridine
- STK368466
Useful catalog search terms
- CAS 174221-86-4
- C30H31N3O7
- JKAMWKLYJHJIFE-YULOIDQLSA-N
Physicochemical data
| InChIKey | JKAMWKLYJHJIFE-YULOIDQLSA-N |
|---|---|
| Sugar substitution | 2'-amino-2'-deoxy |
| 5' protection | 4,4'-dimethoxytrityl |
| Free hydroxyl | 3'-OH |
| InChI | InChI=1S/C30H31N3O7/c1-37-22-12-8-20(9-13-22)30(19-6-4-3-5-7-19,21-10-14-23(38-2)15-11-21)39-18-24-27(35)26(31)28(40-24)33-17-16-25(34)32-29(33)36/h3-17,24,26-28,35H,18,31H2,1-2H3,(H,32,34,36)/t24-,26-,27-,28-/m1/s1 |
| SMILES | COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=CC(=O)NC5=O)N)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 2'-Amino-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-Amino-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0037 and CAS 174221-86-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not a BX Lab lot specification or product-performance claim.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.