Modified Nucleosides
2'-beta-C-Ethynyladenosine
Quick view. A beta-ribofuranosyl adenosine derivative bearing an ethynyl substituent at sugar carbon 2', identified by CAS 640725-76-4. CAS 640725-76-4. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-beta-C-Ethynyladenosine is classified as modified nucleosides (Formula C12H13N5O4; molecular weight 291.26).
2'-beta-C-Ethynyladenosine is useful as a bioorthogonal handle for post-synthetic conjugation to fluorophores, affinity tags, surfaces, peptides or other functional payloads.
For 2'-beta-C-Ethynyladenosine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 2'-C-Ethynyladenosine
Useful catalog search terms
- CAS 640725-76-4
Physicochemical data
| Isomeric SMILES | C#C[C@]1([C@@H]([C@H](O[C@H]1n2cnc3c2ncnc3N)CO)O)O |
|---|---|
| PubChem CID | 11173824 |
| InChIKey | GLMZHZQENASCGE-YUTYNTIBSA-N |
| InChI | InChI=1S/C12H13N5O4/c1-2-12(20)8(19)6(3-18)21-11(12)17-5-16-7-9(13)14-4-15-10(7)17/h1,4-6,8,11,18-20H,3H2,(H2,13,14,15)/t6-,8-,11-,12-/m1/s1 |
| SMILES | C#C[C@]1([C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N)CO)O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 2'-beta-C-Ethynyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-beta-C-Ethynyladenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0618 and CAS 640725-76-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.