Halogenated Nucleosides
2-Chloro-2'-deoxyadenosine
Quick view. We supply 2-Chloro-2'-deoxyadenosine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 4291-63-8. Catalog target purity: Specification on request.
Product profile
2-Chloro-2'-deoxyadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C10H12ClN5O3; molecular weight 285.69).
2-Chloro-2'-deoxyadenosine — It is a substituted purine nucleoside with antileukemic activity
For 2-Chloro-2'-deoxyadenosine, reported solubility: Slightly soluble in water, soluble in dimethyl sulfoxide, slightly soluble in methanol, practically insoluble in acetonitrile. It shows polymorphism (5.9). Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- cladribine
- 1,1-CYCLOHEXANEDIACETIC ACID
- 2CDA
- 2-CL-DADO
- CDA
- CLADRIBINE CDA
- Cyclohexanediacetic acid
- LABOTEST-BB LT01147851
Useful catalog search terms
- CAS 4291-63-8
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s |
|---|---|
| InChIKey | PTOAARAWEBMLNO-HSUXUTPPSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=C(Cl)N=3)N)N=C2)C[C@@H]1O |
| Melting point | 181-185 °C(lit.) |
| Boiling point | 547.6±60.0 °C(Predicted) |
| Density | 2.03±0.1 g/cm3(Predicted) |
| pKa | 13.75±0.60(Predicted) |
| Form | White solid |
| Color | White to Pale Yellow |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2-Chloro-2'-deoxyadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 2-Chloro-2'-deoxyadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0112 and CAS 4291-63-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.