Modified Nucleosides
2'-Deoxy-N2-methylguanosine
Quick view. We supply 2'-Deoxy-N2-methylguanosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 19916-77-9. Catalog target purity: Specification on request.
Product profile
2'-Deoxy-N2-methylguanosine is classified as nucleoside or protected nucleoside intermediate (Formula C11H15N5O4; molecular weight 281.27).
2'-Deoxy-N2-methylguanosine — N2-Methyl-2’-deoxyguanosine is a product from the reaction of formaldehyde with exocyclic amino group of deoxyguanosine. Used as the template in primer extension reactions catalyzed by the Klenow fragment of Escherichia coli DNA polymerase I.
For 2'-Deoxy-N2-methylguanosine, reported solubility: DMSO (Slightly, Sonicated). Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere.
Names and search terms
Confirmed or normalized name variants
- Guanosine, 2′-deoxy-N-methyl-
- N2-METHYL-2'-DEOXYGUANOSINE
- 2′-Deoxy-N -methylguanosine
- 2'-Deoxy-N2-methyl-D-guanosine
- 5-(2-AMINO-6-METHOXYPURIN-9-YL)-2-(HYDROXYMETHYL)OXOLAN-3-OL
Useful catalog search terms
- CAS 19916-77-9
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C11H15N5O4/c1-19-10-8-9(14-11(12)15-10)16(4-13-8)7-2-5(18)6(3-17)20-7/h4-7,17-18H,2-3H2,1H3,(H2,12,14,15) |
|---|---|
| InChIKey | BCKDNMPYCIOBTA-UHFFFAOYSA-N |
| SMILES | COc1nc(=N)[nH]c2c1ncn2C1CC(O)C(CO)O1 |
| Melting point | >210°C (dec.) |
| Density | 1.85±0.1 g/cm3(Predicted) |
| pKa | 9.87±0.20(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-Deoxy-N2-methylguanosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 2'-Deoxy-N2-methylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0307 and CAS 19916-77-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.