Modified Nucleosides
2-Methoxy-2'-deoxyadenosine
Quick view. We supply 2-Methoxy-2'-deoxyadenosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 24757-70-8. Catalog target purity: Specification on request.
Product profile
2-Methoxy-2'-deoxyadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C11H15N5O4; molecular weight 281.27).
2-Methoxy-2'-deoxyadenosine — 2-Methoxy-2''-deoxyadenosine is an impurity in the synthesis of Cladribine, a substituted purine nucleoside with antileukemic activity.
For 2-Methoxy-2'-deoxyadenosine, reported solubility: DMSO (Slightly), Methanol (Slightly). Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2'-Deoxy-2-methoxyadenosine
- Cladribine Impurity B
- Cladribine EP Impurity B
- Cladribine USP Related Compound A
- Adenosine, 2'-deoxy-2-methoxy- (8CI,9CI)
- 9-(2-Deoxy-beta-D-ribofuranosyl)-2-methoxyadenine
- 2-Methoxy-2’-deoxyadenosine (Related substance A of Cladribine)
- 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-2-methoxy-9H-purin-6-amine
Useful catalog search terms
- CAS 24757-70-8
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | 1S/C11H15N5O4/c1-19-11-14-9(12)8-10(15-11)16(4-13-8)7-2-5(18)6(3-17)20-7/h4-7,17-18H,2-3H2,1H3,(H2,12,14,15) |
|---|---|
| InChIKey | HGRICISHTIAZJG-UHFFFAOYSA-N |
| SMILES | [n]2(c3nc(nc(c3nc2)N)OC)C1OC(C(C1)O)CO |
| Boiling point | 659.1±65.0 °C(Predicted) |
| Density | 1.84±0.1 g/cm3(Predicted) |
| pKa | 13.77±0.60(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2-Methoxy-2'-deoxyadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 2-Methoxy-2'-deoxyadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0419 and CAS 24757-70-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.