Modified Nucleotides
2'-O-4'-C-Locked-GMP TEA Salt
Quick view. We supply 2'-O-4'-C-Locked-GMP TEA Salt as a locked-nucleic-acid nucleotide analog for high-affinity modified RNA/DNA research. CAS 1152762-58-7. Catalog target purity: Specification on request.
Product profile
2'-O-4'-C-Locked-GMP TEA Salt is classified as nucleotide or nucleotide analog.
2'-O-4'-C-Locked-GMP TEA Salt can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
For 2'-O-4'-C-Locked-GMP TEA Salt, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Useful catalog search terms
- CAS 1152762-58-7
- Nucleotide or nucleotide analog
- conformationally locked sugar
- Modified Nucleotides
Physicochemical data
| Key chemistry motifs | conformationally locked sugar |
|---|---|
| CAS context | The listed CAS refers to the parent/free-acid identity; confirm the supplied salt or counterion in the current specification. |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 2'-O-4'-C-Locked-GMP TEA Salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-4'-C-Locked-GMP TEA Salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0029 and CAS 1152762-58-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-O-4'-C-Locked-GMP TEA Salt or the named structural feature represented by this product.