2'-O-Me Nucleosides
2'-O-Methyladenosine
Quick view. 2'-O-Methyladenosine is a 2'-O-methyl-modified nucleoside building block for research-use modified-nucleoside and oligonucleotide chemistry. CAS 2140-79-6. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-O-Methyladenosine is classified as 2'-o-methyl nucleoside (Formula C11H15N5O4; molecular weight 281.27).
2'-O-Methyladenosine — A 2'-O-methyl-modified adenosine building block for research-use modified-nucleoside and oligonucleotide chemistry.
For 2'-O-Methyladenosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-O-Me-rA
- 2'-O-Methyl-D-adenosine
- Adenosine, 2'-O-methyl-
Useful catalog search terms
- CAS 2140-79-6
Physicochemical data
| PubChem CID | 102213 |
|---|---|
| InChIKey | FPUGCISOLXNPPC-IOSLPCCCSA-N |
| Modification | methyl ether at the ribose 2'-oxygen |
| InChI | InChI=1S/C11H15N5O4/c1-19-8-7(18)5(2-17)20-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1 |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=CN=C3N)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2-Amino-2'-O-methyladenosine
2'-O-Me Nucleosides · CAS: 80791-87-3
BX-2OMN-00032'-O-Methyl-7-deazaadenosine
2'-O-Me Nucleosides · CAS: 68345-70-0
BX-2OMN-0004N6,2'-O-Dimethyladenosine
2'-O-Me Nucleosides · CAS: 57817-83-1
BX-2OMN-00052'-O-Methylinosine
2'-O-Me Nucleosides · CAS: 3881-21-8
BX-MN-01752'-O-Methylcytidine
2'-O-Me Nucleosides · CAS: 2140-72-9
BX-MN-01782'-O-Methylguanosine
2'-O-Me Nucleosides · CAS: 2140-71-8
Frequently asked questions
Can the package size for 2'-O-Methyladenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0179 and CAS 2140-79-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.