2'-O-Me Nucleosides
2'-O-Methyl-5-methylcytidine
Quick view. 2'-O-Methyl-5-methylcytidine is a cytidine nucleoside bearing 2'-O-methyl and 5-methyl substitutions, with CAS 113886-70-7. CAS 113886-70-7. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-O-Methyl-5-methylcytidine is classified as 2'-o-methyl cytidine nucleoside (Formula C11H17N3O5; molecular weight 271.27).
2'-O-Methyl-5-methylcytidine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 2'-O-Methyl-5-methylcytidine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5-Methyl-2'-O-methylcytidine
- m5Cm
- PubChem CID 18660583
- Wikidata Q82490383
Useful catalog search terms
- CAS 113886-70-7
Physicochemical data
| IUPAC name | 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-5-methylpyrimidin-2-one |
|---|---|
| InChI | InChI=1S/C11H17N3O5/c1-5-3-14(11(17)13-9(5)12)10-8(18-2)7(16)6(4-15)19-10/h3,6-8,10,15-16H,4H2,1-2H3,(H2,12,13,17)/t6-,7-,8-,10-/m1/s1 |
| InChIKey | CNVRVGAACYEOQI-FDDDBJFASA-N |
| SMILES | CC1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OC |
| Structural feature | 2'-O-methyl sugar and 5-methyl cytosine base |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-5-methylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Methyl-5-methylcytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0007 and CAS 113886-70-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.