2'-O-Me Nucleosides
2'-O-Methyl-5'-O-DMTr-5-iodouridine
Quick view. A protected uridine building block combining 2'-O-methyl modification, 5'-O-dimethoxytrityl protection and iodine at uracil C5. CAS 588691-24-1. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-O-Methyl-5'-O-DMTr-5-iodouridine is classified as dmtr-protected 2'-o-methyl-5-iodouridine (Formula C31H31IN2O8; molecular weight 686.50 g/mol).
2'-O-Methyl-5'-O-DMTr-5-iodouridine — Protected 2'-O-methyl uridine building block with a C5 iodine handle.
For 2'-O-Methyl-5'-O-DMTr-5-iodouridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-5-iodo-2'-O-methyluridine
- 5-Iodo-5'-DMT-2'-O-methyluridine
Useful catalog search terms
- 588691-24-1
- VYNNFLLSYDWMCJ-LTGLEFCMSA-N
Physicochemical data
| Protecting group | 5'-O-DMTr |
|---|---|
| InChIKey | VYNNFLLSYDWMCJ-LTGLEFCMSA-N |
| InChI | InChI=1S/C31H31IN2O8/c1-38-22-13-9-20(10-14-22)31(19-7-5-4-6-8-19,21-11-15-23(39-2)16-12-21)41-18-25-26(35)27(40-3)29(42-25)34-17-24(32)28(36)33-30(34)37/h4-17,25-27,29,35H,18H2,1-3H3,(H,33,36,37)/t25-,26-,27-,29-/m1/s1 |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)I)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-5'-O-DMTr-5-iodouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Methyl-5'-O-DMTr-5-iodouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0097 and CAS 588691-24-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.