2'-O-Me Nucleosides
2'-O-Methyl-N2-methylguanosine
Quick view. A guanosine nucleoside carrying methyl substitutions at ribose 2'-O and guanine N2, CAS 135023-21-1. CAS 135023-21-1. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-O-Methyl-N2-methylguanosine is classified as 2'-o-me nucleosides (Formula C12H17N5O5; molecular weight 311.29).
2'-O-Methyl-N2-methylguanosine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 2'-O-Methyl-N2-methylguanosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N2,2'-O-Dimethylguanosine
- N-methyl-2'-O-methylguanosine
- Guanosine, N-methyl-2'-O-methyl-
Useful catalog search terms
- CAS 135023-21-1
- PubChem CID 136381024
Physicochemical data
| PubChem CID | 136381024 |
|---|---|
| InChIKey | OJTAZBNWKTYVFJ-IOSLPCCCSA-N |
| Sugar modification | 2'-O-methyl |
| Nucleobase | Guanine |
| Nucleobase substitution | N2-methylamino |
| InChI | InChI=1S/C12H17N5O5/c1-13-12-15-9-6(10(20)16-12)14-4-17(9)11-8(21-2)7(19)5(3-18)22-11/h4-5,7-8,11,18-19H,3H2,1-2H3,(H2,13,15,16,20)/t5-,7-,8-,11-/m1/s1 |
| SMILES | CNC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-N2-methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Methyl-N2-methylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0015 and CAS 135023-21-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.