Modified Nucleotides
2'-O-MOE-ATP(alpha-S) Lithium Salt
Quick view. A lithium salt of adenosine 5'-alpha-thiotriphosphate bearing a 2'-O-(2-methoxyethyl) substituent and an unprotected 3'-hydroxyl group. A public CAS number is not assigned for this exact form. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-O-MOE-ATP(alpha-S) Lithium Salt is classified as modified nucleotides.
2'-O-MOE-ATP(alpha-S) Lithium Salt is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 2'-O-MOE-ATP(alpha-S) Lithium Salt, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 2'-O-(2-Methoxyethyl)-ATP(alpha-S) Lithium Salt
- 2'-MOE-ATPalphaS Lithium Salt
- 2'-O-(2-Methoxyethyl)-adenosine 5'-alpha-thiotriphosphate lithium salt
Physicochemical data
| Free-acid molecular formula | C13H22N5O13P3S |
|---|---|
| Free-acid molecular weight | 581.32 |
| Salt form | Lithium salt |
| Counterion stoichiometry | Not specified |
| Sugar modification | 2'-O-(2-methoxyethyl) |
| Hydroxyl state | 3' hydroxyl unprotected |
| Phosphate state | 5'-alpha-thiotriphosphate |
| Alpha-phosphorus configuration | Not specified |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-ATP(alpha-S) Lithium Salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-MOE-ATP(alpha-S) Lithium Salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0034, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.