2'-O-MOE Phosphoramidites
5'-O-DMTr-2'-O-(2-methoxyethyl)uridine-3'-CE phosphoramidite
Quick view. A protected uridine phosphoramidite bearing a 2'-O-(2-methoxyethyl) modification, a 5'-DMTr group, and a 3'-cyanoethyl N,N-diisopropylphosphoramidite group. CAS 163759-97-5. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-2'-O-(2-methoxyethyl)uridine-3'-CE phosphoramidite is classified as 2'-o-moe phosphoramidites (Formula C42H53N4O10P; molecular weight 804.86).
5'-O-DMTr-2'-O-(2-methoxyethyl)uridine-3'-CE phosphoramidite — Identity-defined protected 2'-O-MOE uridine CE phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For 5'-O-DMTr-2'-O-(2-methoxyethyl)uridine-3'-CE phosphoramidite, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-U phosphoramidite
- 2'-O-MOE-rU phosphoramidite
- 2'-O-MOE-U-CE phosphoramidite
- DMTr-2'-O-MOE-U-CE phosphoramidite
Useful catalog search terms
- CAS 163759-97-5
Physicochemical data
| Nucleoside | Uridine |
|---|---|
| Sugar modification | 2'-O-(2-Methoxyethyl) (MOE) |
| 5' protection | DMTr |
| 3'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| Base protection | None indicated |
| PubChem CID | 129896826 |
| InChI | InChI=1S/C42H53N4O10P/c1-29(2)46(30(3)4)57(54-25-11-23-43)56-38-36(55-40(39(38)52-27-26-49-5)45-24-22-37(47)44-41(45)48)28-53-42(31-12-9-8-10-13-31,32-14-18-34(50-6)19-15-32)33-16-20-35(51-7)21-17-33/h8-10,12-22,24,29-30,36,38-40H,11,25-28H2,1-7H3,(H,44,47,48)/t36-,38-,39-,40-,57?/m1/s1 |
| InChIKey | ZLOKLUONKGURQI-UAQIPLLRSA-N |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCCOC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-DMTr-2'-O-(2-methoxyethyl)uridine-3'-CE phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-2OMP-0003DMTr-2'-O-MOE-5-Me-rC(DMTr)-3'-CE-Phosphoramidite
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BX-2OMP-0004DMTr-2'-O-MOE-5-Me-rC-3'-CE-Phosphoramidite
2'-O-MOE Phosphoramidites · CAS: 251647-56-0
BX-2OMP-0006DMTr-2'-O-MOE-rA(Bz)-3'-(1-hydroxy-N,N-diisopropyl)phosphoramidite
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BX-2OMP-0007DMTr-2'-O-MOE-rA(DMTr)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-(2-methoxyethyl)uridine-3'-CE phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0062 and CAS 163759-97-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.