Reverse Phosphoramidites
2'-OMe-A(Bz)-CE-Reverse Phosphoramidite
Quick view. We supply 2'-OMe-A(Bz)-CE-Reverse Phosphoramidite as a reverse-direction 2'-O-methyl adenosine amidite for polarity-inverted RNA/ASO synthesis. A public CAS number is not assigned for this exact form. Catalog target purity: Specification on request.
Structure confirmation
This item requires structure confirmation before quotation. Send the target structure, CAS number, SMILES, InChI or drawing for our technical review.
Canonical name plus a structure drawing, SMILES, InChI or unambiguous CAS number.
Protecting groups, stereochemistry, salt or counterion, hydration and requested form.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
2'-OMe-A(Bz)-CE-Reverse Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block.
2'-OMe-A(Bz)-CE-Reverse Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For 2'-OMe-A(Bz)-CE-Reverse Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- Protected oligonucleotide phosphoramidite building block
- 2'-O-methyl modification
- phosphoramidite coupling group
- Reverse Phosphoramidites
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification; phosphoramidite coupling group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-OMe-A(Bz)-CE-Reverse Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-OMe-A(Bz)-CE-Reverse Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-RP-0013, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry.