Modified Nucleosides
2-Thiopseudouridine
Quick view. We supply 2-Thiopseudouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 59464-18-5. Catalog target purity: Specification on request.
Product profile
2-Thiopseudouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12N2O5S; molecular weight 260.267).
2-Thiopseudouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2-Thiopseudouridine, modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
Names and search terms
Confirmed or normalized name variants
- 1,4-Anhydro-1-(4-hydroxy-2-sulfanylpyrimidin-5-yl)pentitol
Useful catalog search terms
- CAS 59464-18-5
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H12N2O5S/c12-2-4-5(13)6(14)7(16-4)3-1-10-9(17)11-8(3)15/h,4-7,12-14H,2H2,(H2,10,11,15,17)/t4-,5-,6-,7+/m1/s |
|---|---|
| InChIKey | DDHOXEOVAJVODV-GBNDHIKLSA-N |
| SMILES | OC[C@H]1O[C@@H](c2cnc(S)nc2O)[C@H](O)[C@@H]1O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Base modifications can tune RNA stability, translation behavior, duplex properties or analytical discrimination versus native bases.
Method limitations
- Modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
These points describe 2-Thiopseudouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2-Thiopseudouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0604 and CAS 59464-18-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2-Thiopseudouridine or the named structural feature represented by this product.