Modified Nucleosides
2-Thiopseudouridine
Quick view. A pseudouridine-derived C-nucleoside in which the pyrimidine C2 carbonyl is replaced by a thioxo group. CAS 59464-18-5. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2-Thiopseudouridine is classified as 2-thio pyrimidine c-nucleoside (Formula C9H12N2O5S; molecular weight 260.27 g/mol).
2-Thiopseudouridine — Reported in the literature as a pyrimidine C5 nucleoside prepared in general syntheses of pseudouridine-related C-nucleosides.
For 2-Thiopseudouridine, modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
Names and search terms
Confirmed or normalized name variants
- 5-(beta-D-Ribofuranosyl)-2-thiouracil
- 1,4-Anhydro-1-(4-hydroxy-2-sulfanylpyrimidin-5-yl)pentitol
Useful catalog search terms
- 59464-18-5
- DDHOXEOVAJVODV-GBNDHIKLSA-N
Physicochemical data
| InChIKey | DDHOXEOVAJVODV-GBNDHIKLSA-N |
|---|---|
| InChI | InChI=1S/C9H12N2O5S/c12-2-4-5(13)6(14)7(16-4)3-1-10-9(17)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,17)/t4-,5-,6-,7+/m1/s1 |
| SMILES | OC[C@H]1O[C@@H](c2cnc(S)nc2O)[C@H](O)[C@@H]1O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Base modifications can tune RNA stability, translation behavior, duplex properties or analytical discrimination versus native bases.
Method limitations
- Modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
These points describe 2-Thiopseudouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
(S)-cEt-rA
Modified Nucleosides · CAS: 1197033-34-3
BX-OP-0069S-Adenosyl-L-methionine (SAM)
Modified Nucleosides · CAS: 485-80-3
BX-MN-01875-(Carboxyhydroxymethyl)uridine
Modified Nucleosides · CAS: 934743-11-0
BX-MN-0719(R)-N6-(2,3-Dihydro-1H-inden-1-yl)adenosine
Modified Nucleosides · CAS: 96392-15-3
BX-MN-01972,2'-Cyclocytidine hydrochloride
Modified Nucleosides · CAS: 10212-25-6
BX-MN-0199N3-Allyluridine
Modified Nucleosides · CAS: 103951-13-9
Frequently asked questions
Can the package size for 2-Thiopseudouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0604 and CAS 59464-18-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not a BX Lab lot specification or product-performance claim.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.