Cyclic Dinucleotides
3',3'-cGAMP
Quick view. 3',3'-cGAMP is a cyclic guanosine-adenosine dinucleotide for research-use cyclic nucleotide chemistry. CAS 849214-04-6. Catalog target purity: >98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3',3'-cGAMP is classified as cyclic dinucleotide (Formula C20H24N10O13P2; molecular weight 674.40).
3',3'-cGAMP — Cyclic dinucleotide reagent for research workflows that specify the counterion-free 3',3'-linked form.
For 3',3'-cGAMP, activity can depend on linkage stereochemistry, receptor variant, cell entry, salt form and assay format; molar calculations should use the exact supplied form.
Names and search terms
Confirmed or normalized name variants
- Cyclic GMP-AMP
Useful catalog search terms
- 3'-3'-cGAMP
- CAS 849214-04-6
Physicochemical data
| Cyclic linkage | 3',3' |
|---|---|
| PubChem CID | 135471108 |
| InChIKey | RFCBNSCSPXMEBK-INFSMZHSSA-N |
| InChI | InChI=1S/C20H24N10O13P2/c21-14-8-15(24-3-23-14)29(4-25-8)18-10(31)12-6(40-18)1-38-45(36,37)43-13-7(2-39-44(34,35)42-12)41-19(11(13)32)30-5-26-9-16(30)27-20(22)28-17(9)33/h3-7,10-13,18-19,31-32H,1-2H2,(H,34,35)(H,36,37)(H2,21,23,24)(H3,22,27,28,33)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1 |
| SMILES | Nc1nc2c(ncn2[C@@H]2O[C@@H]3COP(=O)(O)O[C@H]4[C@@H](O)[C@H](n5cnc6c(N)ncnc65)O[C@@H]4COP(=O)(O)O[C@H]3[C@H]2O)c(=O)[nH]1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Defined linkage isomers and counterion forms allow controlled comparisons across cyclic-dinucleotide assay conditions.
Method limitations
- Activity can depend on linkage stereochemistry, receptor variant, cell entry, salt form and assay format; molar calculations should use the exact supplied form.
These points describe 3',3'-cGAMP or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-CDN-00052'3'-c-di-AM(PS)2 (Rp,Rp) diammonium salt
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Frequently asked questions
Can the package size for 3',3'-cGAMP be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CDN-0004 and CAS 849214-04-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Cyclic Dinucleotides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
- Cyclic G(2',5')pA(3',5')p is the metazoan second messenger produced by cGAS
- STING is a direct innate immune sensor of cyclic di-GMP
- Cyclic di-AMP secreted by Listeria monocytogenes activates a host type I interferon response
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.