Modified Nucleosides
3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine
Quick view. We supply 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 69304-45-6. Catalog target purity: Specification on request.
Product profile
3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine is classified as nucleoside or protected nucleoside intermediate (Formula C22H39N5O5Si; molecular weight 509.752).
3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine — 3,5-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine (CAS# 69304-45-6) is an adenosine nucleoside used as a building block to prepare DNA and RNA duplexes with exonic splicing enhancer activity.
For 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine, storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- 3',5'-TIPDS-Ar
- 3',5'-O-TIPS-rA
- 3',5'-TIPS-Adenosine
- (1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine
- 3',5'-O-(1,1,3,3-Tetraisopropyl- 1,3-Disloxanediyl)Adenosine
- Adenosine, 3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-
- 9-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]adenine
Useful catalog search terms
- CAS 69304-45-6
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C22H39N5O5Si2/c1-12(2)33(13(3)4)29-9-16-19(31-34(32-33,14(5)6)15(7)8)18(28)22(30-16)27-11-26-17-20(23)24-10-25-21(17)27/h10-16,18-19,22,28H,9H2,1-8H3,(H2,23,24,25)/t16-,18-,19-,22-/m1/s |
|---|---|
| InChIKey | KHVLHRYSOPSVJR-WGQQHEPDSA-N |
| SMILES | O1[Si](C(C)C)(C(C)C)O[Si](O[C@H]2[C@H]([C@H](N3C4C(=C(N=CN=4)N)N=C3)O[C@@H]2C1)O)(C(C)C)C(C)C |
| Melting point | 135-139 °C(lit.) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0638 and CAS 69304-45-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.