Amino-modified Nucleosides
3'-Azido-2',3'-dideoxyadenosine
Quick view. A D-configured dideoxyadenosine bearing an azido group at sugar C3', identified by CAS 66323-44-2. CAS 66323-44-2. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-Azido-2',3'-dideoxyadenosine is classified as amino-modified nucleosides (Formula C10H12N8O2; molecular weight 276.25).
3'-Azido-2',3'-dideoxyadenosine — Azido-modified dideoxyadenosine intermediate for nucleoside chemistry.
For 3'-Azido-2',3'-dideoxyadenosine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 3'-Az-ddA
- 3'-N3-ddA
- 3'-Azido-ddA
Useful catalog search terms
- CAS 66323-44-2
- PubChem CID 451362
Physicochemical data
| Sugar modification | 2',3'-Dideoxy with 3'-azido substitution |
|---|---|
| Isomeric SMILES | C1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N)CO)N=[N+]=[N-] |
| InChIKey | XDRZJDXXQHFAAE-RRKCRQDMSA-N |
| PubChem CID | 451362 |
| InChI | InChI=1S/C10H12N8O2/c11-9-8-10(14-3-13-9)18(4-15-8)7-1-5(16-17-12)6(2-19)20-7/h3-7,19H,1-2H2,(H2,11,13,14)/t5-,6+,7+/m0/s1 |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N)CO)N=[N+]=[N-] |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 3'-Azido-2',3'-dideoxyadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-MN-00083'-NH₂-ddG
Amino-modified Nucleosides · CAS: 66323-49-7
BX-MN-01762-Aminoadenosine
Amino-modified Nucleosides · CAS: 2096-10-8
BX-AMN-01343'-beta-Azido-2',3'-dideoxyuridine
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Frequently asked questions
Can the package size for 3'-Azido-2',3'-dideoxyadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0226 and CAS 66323-44-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not a BX Lab lot specification or product-performance claim.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.