Amino-modified Nucleosides
3'-Azido-3-deoxythymidine
Quick view. We supply 3'-Azido-3-deoxythymidine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 30516-87-1. Catalog target purity: Specification on request.
Product profile
3'-Azido-3-deoxythymidine is classified as nucleoside or protected nucleoside intermediate (Formula C10H13N5O5; molecular weight 283.24).
3'-Azido-3-deoxythymidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-Azido-3-deoxythymidine, reported solubility: H₂O: 50 mg/mL. Storage: −20°C.
Names and search terms
Confirmed or normalized name variants
- zidovudine
- 1-(4-azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1h-pyrimidine-2,4-dione
- AZIDOTHYMIDINE
- AZT
- 3’-azido-3’-deoxy-thymidin
- bwa509u
- retrovir
- ZIDOVUDINE. ANTI-VIRAL
Useful catalog search terms
- CAS 30516-87-1
- Nucleoside or protected nucleoside intermediate
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle; amine functionality |
|---|---|
| InChI | InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s |
| InChIKey | HBOMLICNUCNMMY-BWZBUEFSSA-N |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N=[N+]=[N-] |
| Melting point | 113-115 °C (lit.) |
| Boiling point | 410.43°C (rough estimate) |
| Density | 1.3382 (rough estimate) |
| pKa | pKa 9.53(H₂O t = 25.0±0.1 I = 0.00) (Uncertain) |
| Form | Powder |
| Color | White to Off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 3'-Azido-3-deoxythymidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-Azido-3-deoxythymidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0202 and CAS 30516-87-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 3'-Azido-3-deoxythymidine or the named structural feature represented by this product.