Halogenated Nucleosides
3'-beta-C-Ethynyl-5-fluorouridine
Quick view. A 5-fluorouridine nucleoside bearing a beta-C-ethynyl sugar modification. A public CAS number is not assigned for this exact form. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-beta-C-Ethynyl-5-fluorouridine is classified as halogenated nucleosides (Formula C11H11FN2O6; molecular weight 286.21 g/mol).
3'-beta-C-Ethynyl-5-fluorouridine is useful as a bioorthogonal handle for post-synthetic conjugation to fluorophores, affinity tags, surfaces, peptides or other functional payloads.
For 3'-beta-C-Ethynyl-5-fluorouridine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Physicochemical data
| InChIKey | RXMHNLRVIZFETP-YRCORFKGSA-N |
|---|---|
| InChI | InChI=1S/C11H11FN2O6/c1-2-11(19)6(4-15)20-9(7(11)16)14-3-5(12)8(17)13-10(14)18/h1,3,6-7,9,15-16,19H,4H2,(H,13,17,18)/t6-,7+,9-,11-/m1/s1 |
| SMILES | C#C[C@]1([C@H](O[C@H]([C@@H]1O)N2C=C(C(=O)NC2=O)F)CO)O |
| Canonical SMILES | C#C[C@]1([C@H](O[C@H]([C@@H]1O)N2C=C(C(=O)NC2=O)F)CO)O |
| PubChem CID | 10827042 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-beta-C-Ethynyl-5-fluorouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Trifluridine
Halogenated Nucleosides · CAS: 70-00-8
BX-HN-00026-Chloropurine 2'-deoxyriboside
Halogenated Nucleosides · CAS: 4594-45-0
BX-HN-00038-Chloro-2'-deoxyadenosine
Halogenated Nucleosides · CAS: 85562-55-6
BX-HN-00042'-Chloro-2'-deoxycytidine
Halogenated Nucleosides · CAS: 10212-19-8
BX-HN-00055-Bromo-2'-deoxycytidine
Halogenated Nucleosides · CAS: 1022-79-3
BX-HN-01535-Fluoro-2'-deoxycytidine
Halogenated Nucleosides · CAS: 10356-76-0
Frequently asked questions
Can the package size for 3'-beta-C-Ethynyl-5-fluorouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0206, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.